serum level of interleukin 17 in patients with erosive and non erosive oral lichen planus
نویسندگان
چکیده
background and aims. oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (il-17) level in patients with erosive and non-erosive oral lichen planus. materials and methods. this descriptive analytical study included 24 patients with erosive oral lichen planus (eolp), 24 patients with non-erosive oral lichen planus (neolp) and 24 healthy volunteered as control. blood samples of the subjects underwent elisa, using special kits, to determine serum interleukin-17 levels. data was analyzed using with descriptive statistic, chi-square test, and one-way anova and tukey post-hoc test with spss 16 software. results. eolp patients showed a high level of serum il-17 compared with neolp patents and control groups (eolp=184.16 ± 12.41 pg/ml, neolp=106.09±10.78 pg/ml, control=15.50 ± 4.34 pg/ml, p - 0.001). conclusion. high level of serum il-17 in erosive oral lichen planus patients compared to the non-erosive type and healthy individuals may be the reason for higher inflammation and atrophy in the erosive type.
منابع مشابه
Serum Level of Interleukin 17 in Patients with Erosive and Non erosive Oral Lichen Planus
BACKGROUND AND AIMS Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus. MATERIALS AND METHODS This descriptive analytical study in...
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STATEMENT OF PROBLEM Lichen planus is a chronic inflammatory immunologic-based disease involving skin and mucosa. This disease is generally divided into two categories: erosive and non-erosive. Many etiologic factors are deliberated regarding the disease; however, the disorders of immune system and the role of cytotoxic T-lymphocytes and monocytes are more highlighted. Zinc is an imperative ele...
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متن کاملErosive Palmoplantar Lichen Planus
Erosive palmoplantar lichen planus (LP), also known as ulcerative or bullous LP, was first described by Cram et al. in 1966 as a rare variant of LP that can affect mucous membranes, palms, and soles. It presents clinically as erythematous, ulcerated plaques that run an extremely chronic course and are resistant to all types of treatment. The patient was an 84-year-old woman with a personal hist...
متن کامل[Erosive palmoplantar lichen planus].
Erosive palmoplantar lichen planus (LP), also known as ulcerative or bullous LP, was first described by Cram et al. in 1966 as a rare variant of LP that can affect mucous membranes, palms, and soles. It presents clinically as erythematous, ulcerated plaques that run an extremely chronic course and are resistant to all types of treatment. The patient was an 84-year-old woman with a personal hist...
متن کاملimmunohistochemical evaluation of ki-67 expression in erosive and non-erosive oral lichen planus
conclusions since ki-67 is extensively accepted as an important biomarker in diagnosis, prognosis and treatment of cancerous and precancerous lesions, a high degree of presence of this biomarker in chronic precancerous lesions, such as erosive olp, can be of great use in prognosis and suggested treatments. objectives this study aimed to evaluate ki-67 expression in erosive and non-erosive oral ...
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عنوان ژورنال:
journal of dental research, dental clinics, dental prospectsجلد ۷، شماره ۲، صفحات ۹۱-۹۴
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